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K1750

α-Ketoglutaric acid

≥98.5% (NaOH, titration)

Synonym(s):

2-Oxoglutaric acid, 2-Oxopentanedioic acid

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About This Item

Linear Formula:
HOOCCH2CH2COCOOH
CAS Number:
328-50-7
Molecular Weight:
146.10
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
57654314
EC Number:
206-330-3
Beilstein/REAXYS Number:
1705689
MDL number:
MFCD00004165
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Quality Level

200

assay

≥98.5% (NaOH, titration)

form

powder

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

OC(=O)CCC(=O)C(O)=O

InChI

1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChI key

KPGXRSRHYNQIFN-UHFFFAOYSA-N

General description

α-Ketoglutaric acid (α-KG) is produced in the tricarboxylic acid cycle.[1]

Application

α-Ketoglutaric acid (α-KG) has been used:
  • to study its effects on swine fecal microflora in an in vitro fermentation system[2]
  • to study its effects on the activation of CD8+ T-cells[3]
  • as a substrate in glutamate oxaloacetate transaminase (GOT2) mitochondrial lysate assay[4]

Biochem/physiol Actions

α-Ketoglutaric acid (α-KG) has a wide range of applications in the animal feed, food, pharmaceutical and fine chemistry industries.[1]

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This Item
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α-Ketoglutaric acid ≥98.5% (NaOH, titration)

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Sigma-Aldrich

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α-Ketoglutaric acid 99.0-101.0% (T)

Sigma-Aldrich

75890

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α-Ketoglutaric acid analytical standard

Supelco

61234

α-Ketoglutaric acid

assay

≥98.5% (NaOH, titration)

assay

≥98.5% NaOH basis (titration)

assay

99.0-101.0% (T)

assay

99.0-101.0% (T)

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless

solubility

H2O: 1 g/10 mL, clear to slightly hazy, colorless to almost colorless

solubility

-

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

-

form

powder

form

powder or crystals

form

crystals

form

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

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pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP3381
BCCN7014
BCCM9745
0000424438
0000424438

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Long Liu et al.
Journal of biotechnology, 164(1), 97-104 (2013-01-22)
Currently, α-ketoglutaric acid (α-KG) is industrially produced by multi-step chemical synthesis, which can cause heavy environmental pollution. Here we reported a simple one-step approach for the production of α-KG by transforming l-glutamic acid with an engineered l-amino acid deaminase (l-AAD)
G Biagi et al.
Journal of animal science, 85(5), 1184-1191 (2007-02-14)
Adding organic acids to piglet diets is known to be helpful in overcoming postweaning syndrome, and butyric acid is known to be the main energy source for the epithelial cells of the large intestine and the terminal ileum. This study
J Kitaura et al.
European journal of pediatrics, 158(5), 410-413 (1999-05-20)
Two cases of hyperinsulinaemic hypoglycaemia associated with persistent hyperammonaemia in unrelated infants of 7 days and 4 months of age are reported. Blood ammonia levels were 100-300 micromol/l (normal values <40 micromol/l). The hyperammonaemia was asymptomatic and not associated with
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Global Trade Item Number

SKUGTIN
K1750-100G04061833868065
K1750-1KG04061833868072

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