C9867

CGK733

≥98% (HPLC), solid

• Synonym(s): 2,2-Diphenyl-n-(2,2,2-trichloro-1-[3-(4-fluoro-3-nitrophenyl)thioureido]ethyl)acetamide
• Empirical Formula (Hill Notation): C₂₃H₁₈Cl₃FN₄O₃S
• CAS Number: 905973-89-9
• Molecular Weight: 555.84
• NACRES: NA.77
• PubChem Substance ID: 24724454
• UNSPSC Code: 12352200
• MDL number: MFCD09038682
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: [O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c3ccccc3)C(Cl)(Cl)Cl)ccc1F
• InChI: 1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)
• InChI key: HLCDNLNLQNYZTK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Originally published as a selective ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) kinase inhibitor, which causes reversible reprogramming of cellular lifespan, conferred robust growth to senescent cells that had ceased proliferation.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable