C6240

CITCO

≥98% (HPLC), androstane receptor agonist, solid

• Synonym(s): 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
• Empirical Formula (Hill Notation): C₁₉H₁₂N₃OCl₃S
• CAS Number: 338404-52-7
• Molecular Weight: 436.74
• UNSPSC Code: 12352203
• PubChem Substance ID: 24724448
• NACRES: NA.77
• MDL number: MFCD00139608
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• Product Name: CITCO, ≥98% (HPLC), solid
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: DMSO: soluble 28 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4
• InChI: 1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+
• InChI key: ZQWBOKJVVYNKTL-AUEPDCJTSA-N

Description

General description

CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.

Application

CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.

Biochem/physiol Actions

CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves