C6022

Cyproheptadine hydrochloride sesquihydrate

≥98% (TLC), solid

• Synonym(s): Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride, hydrate (2:3)
• Empirical Formula (Hill Notation): C₂₁H₂₁N·HCl·1.5H₂O
• CAS Number: 41354-29-4
• Molecular Weight: 350.88
• EC Number: 213-535-1
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278082
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥98% (TLC)
• form: solid
• color: white to slightly yellow
• solubility: ethanol: soluble; methanol: soluble
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• SMILES string: Cl.CN1CCC(\CC1)=C2/c3ccccc3C=Cc4ccccc24
• InChI: 1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H,12-15H2,1H3;2*1H;3*1H2
• InChI key: ZEAUHIZSRUAMQG-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Description

Application

Cyproheptadine hydrochloride sesquihydrate has been used in:

• testing anti-inflammatory activity in serotonin receptor (5-HT) induced inflammation
• the inhibition of 5-HT in in vivo and in vitro bioassays in crabs
• the inhibition of 5-HT in embryo physiological experiments

inhibition of calcitonin gene related peptide (CGRP)

Biochem/physiol Actions

Cyproheptadine hydrochloride sesquihydrate is a serotonin receptor (5-HT2/5-HT1C) antagonist, H1 histamine receptor antagonist and an antipruritic. The inhibition of 5-HT by cyproheptadine improves cognitive function in schizophrenia disorder. Cyproheptadine is effective for treating functional gastrointestinal disorders (FGIDs). Food and Drug Administration (FDA) approved cyproheptadine, has antidepressant and antiplatelet functionality. It may be effective in treating thromboembolic disorders. Cyproheptadine inhibits lysine methyltransferase 7/9 (Set7/9) leading to a decrease in estrogen receptor (ERα) expression and growth arrest in breast cancer cells.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301,H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves