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Conduritol B epoxide

Name: Conduritol B epoxide
Brand: SIGMA

powder, ≥95% (TLC)

Synonym(s):

1,2-Anhydro-myo-inositol

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About This Item

CAS Number:

6090-95-5

UNSPSC Code:

12352119

PubChem Substance ID:

24892783

NACRES:

NA.32

MDL number:

MFCD00077326

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Properties

Product Name

Conduritol B epoxide,

biological source

synthetic (organic)

Quality Segment

100

assay

≥95% (TLC)

form

powder

solubility

water: 20 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

OC1C(O)C(O)C2OC2C1O

InChI

1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H

InChI key

ZHMWOVGZCINIHW-UHFFFAOYSA-N

Description

General description

Conduritol B epoxide (CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.

Application

Conduritol B epoxide has been used as an inhibitor of GBA1 to discriminate between acid β-glucosidase (GBA1) and non-lysosomal β-glucosidase (GBA2) activity in β-glucosidase activity assay. It has also been used as a selective glucocerebrosidase (GCase) inhibitor.

Biochem/physiol Actions

Conduritol B epoxide (CBE) is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).

β-Glucosidase inhibitor

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This Item	234599	C9510	850141P
Sigma-Aldrich C5424 Conduritol B epoxide	Sigma-Aldrich 234599 Conduritol B Epoxide	Sigma-Aldrich C9510 Pyrocatechol	Avanti 850141P 16:0 PI
description -	description Conduritol B Epoxide, CAS 6090-95-5, is an irreversible Inhibitor of glucocerebrosidase in neurons. Also inhibits α-glucosidase activity in a variety of species.	description ≥99%	description 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-myo-inositol) (ammonium salt), powder
biological source synthetic (organic)	biological source -	biological source synthetic (organic)	biological source -
assay ≥95% (TLC)	assay ≥98% (HPLC)	assay ≥99%	assay >99% (TLC)
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level -
form powder	form solid	form powder	form powder
storage temp. 2-8°C	storage temp. −20°C	storage temp. room temp	storage temp. −20°C
solubility water: 20 mg/mL, clear, colorless to faintly yellow	solubility DMSO: soluble, water: soluble	solubility water: 50 mg/mL, clear, colorless to faintly yellow	solubility -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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