42602

Propionyl-L-carnitine

≥94.0% (HPLC), suitable for LC/MS

• Synonym(s): (2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt, L-Carnitine propionyl ester, C3-Carnitine, Propanoyl-L-carnitine
• Empirical Formula (Hill Notation): C₁₀H₁₉NO₄
• CAS Number: 20064-19-1
• Molecular Weight: 217.26
• UNSPSC Code: 12352209
• PubChem Substance ID: 329756246
• NACRES: NA.26
• MDL number: MFCD00870024

Properties

• Product Name: Propionyl-L-carnitine, ≥94.0% (HPLC)
• Quality Segment: 100
• assay: ≥94.0% (HPLC)
• form: powder or crystals
• optical activity: [α]/D -23±3°, c = 1 in H₂O
• technique(s): LC/MS: suitable
• impurities: ≤10% water (calcd. from elemental analysis)
• color: white to off-white
• storage temp.: 2-8°C
• SMILES string: [O-]C(C[C@@H](OC(CC)=O)C[N+](C)(C)C)=O
• InChI: 1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1
• InChI key: UFAHZIUFPNSHSL-MRVPVSSYSA-N

Description

General description

Propionyl-L-carnitine (PLC) is a short-chain fatty acid ester derivative of carnitine.[1]

Application

Propionyl-L-carnitine has been used as a standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS).[2]

Biochem/physiol Actions

Propionyl-L-carnitine (PLC) plays a key role in lipid and carbohydrate metabolism. It provides substrates to the ischemic muscle for energy production and ATP generation.[1] PLC has the potential to treat severe peripheral arterial disease and chronic heart failure.[3] It is present in high abundance in the urine of patients with methylmalonyl-CoA mutase (MUT) deficiency, together with methylmalonic acid. MUT is a mitochondrial enzyme that catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable