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07039

(R)-(+)-α-Lipoic acid

≥98.0% (HPLC)

Synonym(s):

(R)-(+)-1,2-Dithiolane-3-pentanoic acid, (R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid

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About This Item

Empirical Formula (Hill Notation):
C8H14O2S2
CAS Number:
1200-22-2
Molecular Weight:
206.33
UNSPSC Code:
12352202
PubChem Substance ID:
329748332
NACRES:
NA.32
MDL number:
MFCD01631142
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Quality Segment

100

assay

≥98.0% (HPLC)

optical purity

enantiomeric excess: ≥98.0% (HPLC)

mp

48-52 °C (lit.)

storage temp.

−20°C

InChI

1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1

InChI key

AGBQKNBQESQNJD-SSDOTTSWSA-N

Biochem/physiol Actions

(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

identity confirmed by LC-MS

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Storage Class

11 - Combustible Solids

wgk

WGK 3

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