The solution stability has not been tested. However, literature research suggests that enrofloxacin solutions dissolved in organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO) stored under frozen conditions can typically remain stable for approximately 26 to 52 weeks (6 to 12 months). The exact stability can depend on factors such as concentration, formulation, and specific storage conditions.
17849
Enrofloxacin
≥99.0%
Synonym(s):
Baytril
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About This Item
Empirical Formula (Hill Notation):
C19H22FN3O3
CAS Number:
Molecular Weight:
359.39
UNSPSC Code:
41116105
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5307824
Pricing and availability is not currently available.
Quality Segment
assay
≥99.0%, 99.0-101.0% (dried substance)
form
powder or crystals
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4
InChI
1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)
InChI key
SPFYMRJSYKOXGV-UHFFFAOYSA-N
General description
Chemical structure: fluoroquinolone
Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.[1][2][3]
Application
Enrofloxacin has been used:
- to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells[1]
- to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)[2]
- as an analyte in a chemiluminescence reagent system[4]
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This Item | |||
|---|---|---|---|
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action - | mode of action DNA synthesis | interferes, enzyme | inhibits |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria |
| form powder or crystals | form - | form - | form - |
| assay ≥99.0%, 99.0-101.0% (dried substance) | assay - | assay - | assay - |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level 100 |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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Is it possible to store the drug frozen for long-term preservation after dissolving it in organic solvents?
1 answer-
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What is the solubility of Antibiotic Question 17849 in water? This is intended for use in a mouse experiment involving drinking water.
1 answer-
The substance is not soluble in water. It has a solubility of 1mg/ml in organic solvents such as DMSO and 10 mg/ml in DMF. Additionally, it is suggested to try if the drug dissolves in (2-Hydroxypropyl)-β-cyclodextrin solution H5784.
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