This product may be reconstituted in water at 0.1-1.0 mg/mL. Stock solutions are stable for up to 1 week when refrigerated at 2 - 8°C. For extended storage, further dilute the prepared stock solution with working buffer containing a carrier protein such as albumin (0.1 - 1.0%) or trehalose (5%). Dilute solutions may then be stored in working aliquots at -20 or -80°C. Avoid repeated freeze/thaw cycles.
GF306
IGF-I Protein, Human Recombinant Animal Free
The Insulin-like growth factor I protein(or IGF-1 protein), also known as somatomedin C, is the dominant effector of growth hormone & is structurally homologous to proinsulin. Manufactured using all non-animal reagents.
Synonym(s):
IGF-1, IGF1, Insulinlike Growth Factor I, Insulinlike Growth Factor 1, Mechano growth factor, Somatomedin-C, IGFI
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.77
eCl@ss:
32160405
Assay:
>98% (SDS-PAGE and HPLC)
Pricing and availability is not currently available.
Quality Segment
assay
>98% (SDS-PAGE and HPLC)
impurities
<0.1 μg/mg protein endotoxin (<1EU/μg)
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
-10 to -25°C
General description
Insulinlike growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.
Product Source: E. coli
Application
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Biochem/physiol Actions
Cross Reactivty
Mouse, Rat, Horse, Pig, Cow, Sheep, Monkey, Chicken, Tiger Salamander, Bacteria, Frog
Mouse, Rat, Horse, Pig, Cow, Sheep, Monkey, Chicken, Tiger Salamander, Bacteria, Frog
Physical form
Product is filtered through a 0.2 micron filter before lyophilization.
Recombinant animal free human IGF-I is manufactured using all non-animal reagents
Preparation Note
Store at -20°C for up to 6 months from date of receipt.
Analysis Note
Bioactivity assay: The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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This Item | |||
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| description The Insulin-like growth factor I protein(or IGF-1 protein), also known as somatomedin C, is the dominant effector of growth hormone & is structurally homologous to proinsulin. Manufactured using all non-animal reagents. | description - | description The Neurotrophin-4 protein (or NT-4 protein), also known as NT-5 protein, is a member of the NGF family of neuronal & epithelial growth factors. | description The Stem cell factor also known as ckit ligand, mast cell growth factor & steel factor (SLF), is a widely expressed 28-40kDa type I transmembrane glycoprotein. Recombinant animal free human SCF is manufactured using all non-animal reagents. |
| assay >98% (SDS-PAGE and HPLC) | assay - | assay >98% (SDS-PAGE and HPLC) | assay >98% (SDS-PAGE and HPLC) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| storage temp. -10 to -25°C | storage temp. -10 to -25°C | storage temp. -10 to -25°C | storage temp. -10 to -25°C |
| impurities <0.1 μg/mg protein endotoxin (<1EU/μg) | impurities <0.1 μg/mg protein endotoxin (<1 EU/μg) | impurities <0.1 μg/mg protein endotoxin (<1EU/μg) | impurities <0.1 μg/mg protein endotoxin (<1EU/μg) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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