520222
PPACK dihydrochloride
≥80% (HPLC), solid, thrombin inhibitor, Calbiochem®
Synonym(s):
PPACK, Dihydrochloride
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About This Item
Product Name
PPACK, Dihydrochloride, PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiometry.
description
Merck USA index - 14, 7699
Quality Segment
assay
≥80% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
white
solubility
water: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
ClCC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)Cc2ccccc2)CCCN=C(N)N.Cl.Cl
General description
Biochem/physiol Actions
Thrombin
Packaging
Preparation Note
Other Notes
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.
Legal Information
Disclaimer
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This Item | |||
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| description PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiometry. | description Potent and specific irreversible inhibitor of plasma and glandular kallikreins. | description Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. | description Cell-permeable and irreversible inhibitor of adenylate cyclase (IC50 = 250 µM). |
| form solid | form solid | form powder | form solid |
| assay ≥80% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility water: 100 mg/mL | solubility water: 100 mg/mL | solubility DMSO: 5 mg/mL, water: 1 mg/mL | solubility water: 3 mg/mL, DMSO: 10 mg/mL, ethanol: 5 mg/mL |
![PPACK, Dihydrochloride PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiometry.](/deepweb/assets/sigmaaldrich/product/images/403/286/e04cdb4e-07b0-4353-b8e5-13b915eae16c/640/e04cdb4e-07b0-4353-b8e5-13b915eae16c.jpg)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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