475882-M

ML-9, Hydrochloride

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM).

• Synonym(s): ML-9, Hydrochloride, 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl
• Empirical Formula (Hill Notation): C₁₅H₁₇ClN₂O₂S · xHCl
• CAS Number: 105637-50-1
• Molecular Weight: 324.83 (free base basis)
• UNSPSC Code: 12352200
• MDL number: MFCD00065525
• NACRES: NA.77
• Assay: ≥98% (TLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Properties

• Quality Segment: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: white
• solubility: 50% ethanol: 10 mg/mL
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(N3CCNCCC3)c1c2c(c(ccc2)Cl)ccc1.[Cl-].[H+]
• InChI: 1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
• InChI key: ZNRYCIVTNLZOGI-UHFFFAOYSA-N

Description

General description

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.

Biochem/physiol Actions

Primary Target
Mlck

Target K_i: 3.8 µM, 32 µM, 54 µM against myosin light chain kinase, protein kinase A, and protein kinase C, respectively

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Further dilute with aqueous buffer just prior to use.

Other Notes

Reig, J.A., et al. 1993. Neurochem. Res. 18, 317.
Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun.143, 1045.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun.140, 280.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable