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Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

Synonym(s):

Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt, ATP-γ-S, 4Li

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About This Item

Empirical Formula (Hill Notation):
C10H12N5O12P3S · 4Li
CAS Number:
Molecular Weight:
546.98
MDL number:
UNSPSC Code:
12352208
NACRES:
NA.51

Quality Level

Assay

≥85% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

impurities

<10% ADP

color

white

solubility

water: 10 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1

InChI key

DWQFDOIBOYDYKH-KWIZKVQNSA-J

General description

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases activity of Ca2+-activated K+ channels. Used as an inhibitor of ATP-dependent enzyme systems.
A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases the activity of Ca2+-activated K+ channels. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

Application


  • Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.: This study explores the role of purinergic receptors and the NOD-like receptor-family protein 3 (NLRP3) inflammasome pathway in cytokine release induced by adenosine triphosphate (ATP) in macrophages. The findings suggest potential therapeutic targets for inflammatory diseases (Gicquel et al., 2014).

  • Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries.: The study demonstrates that extracellular ATP enhances flow-induced vasodilation in small mesenteric arteries in rats, indicating a significant role of ATP in vascular function and potential implications for cardiovascular therapies (Liu et al., 2004).

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.

Other Notes

Troadec, J.D., et al. 1999. Pflugers Arch. 437, 745.
Chung, S., et al. 1991. Science253, 560.
Litosch, I., and Fain, J.N. 1986. Life Sci. 39, 187.
Chrysogelos, S., et al. 1983. J. Biol. Chem.258, 12624.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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