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SML2295

Sigma-Aldrich

Dimethyoxy-etomidate

≥98% (HPLC)

Synonym(s):

(R)-ethyl 1-(1-(3,5-dimethoxyphenyl)ethyl)-1H-imidazole-5-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C16H20N2O4
CAS Number:
2300142-82-7
Molecular Weight:
304.34
UNSPSC Code:
12352200

Assay

≥98% (HPLC)

form

oil

color

colorless to light brown

storage temp.

2-8°C

SMILES string

C[C@@H](N1C=NC=C1C(OCC)=O)C2=CC(OC)=CC(OC)=C2

InChI

1S/C16H20N2O4/c1-5-22-16(19)15-9-17-10-18(15)11(2)12-6-13(20-3)8-14(7-12)21-4/h6-11H,5H2,1-4H3/t11-/m1/s1

InChI key

JETTTZITBCWAQX-LLVKDONJSA-N

Biochem/physiol Actions

Dimethyoxy-etomidate is a phenyl ring substituted etomidate analog.
Dimethyoxy-etomidate is a potent suppressor of adrenocortical steroid synthesis by inhibiting steroid 11β-hydroxylase. Dimethyoxy-etomidate is essentially divided of etomidate′s GABAA receptor positive modulatory and sedative-hypnotic activities.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
McGrath M, et al.
BMC Pharmacology & Toxicology, 20, 1-9 (2019)
Megan McGrath et al.
The Journal of pharmacology and experimental therapeutics, 364(2), 229-237 (2017-12-06)
Cushing's syndrome is characterized by the overproduction of adrenocortical steroids. Steroidogenesis inhibitors are mainstays of medical therapy for Cushing's syndrome; unfortunately, adverse side effects and treatment failures are common with currently available drugs. The general anesthetic induction agent etomidate is

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