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SAB4501657

Sigma-Aldrich

Anti-Keratin 14 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CK-14, Cytokeratin-14, K14, Keratin type I cytoskeletal 14

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 51 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P02533

UniProt accession no.

P02533

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KRT14(3861)

General description

Anti-Keratin 14 Antibody detects endogenous levels of total Keratin 14 protein.
CK14/ KRT14 (keratin 14) is one of the cytokeratin isotypes of human cells. It is the intermediate filament protein, which is the feature of epithelial cells. It is located in human chromosome 17q21.

Immunogen

The antiserum was produced against synthesized peptide derived from human Keratin 14.

Immunogen Range: 1-50

Biochem/physiol Actions

CK14/ KRT14 (keratin 14) participates in the collective invasion of salivary adenoid cystic carcinoma (SACC). Mutations in KRT14 results in epidermolysis bullosa simplex.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maree Bilandzic et al.
Cancers, 11(9) (2019-08-25)
Epithelial ovarian cancer metastasis is driven by spheroids, which are heterogeneous cancer cell aggregates released from the primary tumour mass that passively disseminate throughout the peritoneal cavity to promote tumour spread, disease recurrence, and acquired chemoresistance. Despite their clinical importance
Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma.
Gao XL, et al.
PLoS ONE, 12(2), e0171341-e0171341 (2017)
KRT14 Haploinsufficiency Results in Increased Susceptibility of Keratinocytes to TNF-?-Induced Apoptosis and Causes Naegeli?Franceschetti?Jadassohn Syndrome.
Lugassy J, et al.
The Journal of Investigative Dermatology, 128(6), 1517-1524 (2008)
Lilian M Fennell et al.
The EMBO journal, 39(24), e103303-e103303 (2020-11-21)
HOIP, the catalytic component of the linear ubiquitin chain assembly complex (LUBAC), is a critical regulator of inflammation. However, how HOIP itself is regulated to control inflammatory responses is unclear. Here, we discover that site-specific ubiquitination of K784 within human
Truong San Phan et al.
Science advances, 7(5) (2021-01-31)
Glucocorticoids (GC), synthesized by the 11β-hydroxylase (Cyp11b1), control excessive inflammation through immunosuppressive actions. The skin was proposed to regulate homeostasis by autonomous GC production in keratinocytes. However, their immunosuppressive capacity and clinical relevance remain unexplored. Here, we demonstrate the potential
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