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G0923

Sigma-Aldrich

Golgicide A

≥98% (HPLC)

Synonym(s):

6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline, CID 25113626, GCA

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About This Item

Empirical Formula (Hill Notation):
C17H14F2N2
CAS Number:
1005036-73-6
Molecular Weight:
284.30
MDL number:
MFCD27937048
UNSPSC Code:
12352200
PubChem Substance ID:
329799717
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL

storage temp.

room temp

SMILES string

Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c4cccnc4

InChI

1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1

InChI key

NJZHEQOUHLZCOX-FTLRAWMYSA-N

Related Categories

Application

Golgicide A has been used as an inhibitor in retrotransposition assays and as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells.

Biochem/physiol Actions

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1.
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000330606
0000330608
0000326389
0000330608
0000330606

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Hilary C Martin et al.
Molecular biology and evolution, 35(5), 1238-1252 (2018-04-25)
The platypus is an egg-laying mammal which, alongside the echidna, occupies a unique place in the mammalian phylogenetic tree. Despite widespread interest in its unusual biology, little is known about its population structure or recent evolutionary history. To provide new
Shi-Min Yuan et al.
Brazilian journal of cardiovascular surgery, 34(4), 472-479 (2019-08-28)
The roles that aortitis plays in the development of annuloaortic ectasia (AAE) remain uncertain, while clinical features of AAE in arteritis are largely unknown. This study was designed to highlight the clinical features of AAE, the treatments of choice, and
Don Gilden et al.
Neurology, 84(19), 1948-1955 (2015-02-20)
Varicella-zoster virus (VZV) infection may trigger the inflammatory cascade that characterizes giant cell arteritis (GCA). Formalin-fixed, paraffin-embedded GCA-positive temporal artery (TA) biopsies (50 sections/TA) including adjacent skeletal muscle and normal TAs obtained postmortem from subjects >50 years of age were
Sravani Banerjee et al.
PLoS pathogens, 14(5), e1007086-e1007086 (2018-05-22)
RNA viruses induce specialized membranous structures for use in genome replication. These structures are often referred to as replication organelles (ROs). ROs exhibit distinct lipid composition relative to other cellular membranes. In many picornaviruses, phosphatidylinositol-4-phosphate (PI4P) is a marker of
Danelle K Seymour et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7317-E7326 (2016-11-03)
The ubiquity of nonparental hybrid phenotypes, such as hybrid vigor and hybrid inferiority, has interested biologists for over a century and is of considerable agricultural importance. Although examples of both phenomena have been subject to intense investigation, no general model
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