F3380
Factor V Activating Enzyme from Russell′s viper venom
lyophilized powder, 20 units/mg protein
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
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Application
Factor V activating enzyme from Russell′s viper venom (RVV) is a single-chain glycoprotein that is involved in the rapid clotting of blood. Factor V circulates in the blood as an inactive cofactor and must be activated by proteases such as Factor V activating enzyme from RVV . This product may be useful in studying the blood coagulation cascade as well as the inherited deficiency called parahemophilia .
Biochem/physiol Actions
Factor V activator for RVV contains fucose, mannose, galactose, glucosamine, and neuraminic acid. Factor V activating enzyme from RVV is an arginine esterase that is sensitive to diisopropyl fluorophosphate (DFP) .
Unit Definition
One unit will increase the Factor V activity in 0.1 mL of fresh normal human plasma by at least 2× after incubation for 3 min at 37 °C.
Physical form
Stabilized in albumin and sodium chloride.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Kenneth Segers et al.
Proteins, 64(4), 968-984 (2006-06-30)
Blood coagulation factor V (FV) is a multifunctional protein that circulates in human plasma as a precursor molecule which can be activated by thrombin or activated factor X (FXa) in order to express its cofactor activity in prothrombin activation. FV
Laura M Haynes et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(12), 2877-2883 (2012-10-02)
Rivaroxaban is an oral anticoagulant that directly targets both free factor Xa and factor Xa in complex with its protein cofactor, factor Va, in the prothrombinase complex. It is approved in the United States for the prophylaxis of deep vein
Rinku Majumder et al.
The Journal of biological chemistry, 286(41), 35535-35542 (2011-08-24)
Constituents of platelet membranes regulate the activity of the prothrombinase complex. We demonstrate that membranes containing phosphatidylcholine and phosphatidylethanolamine (PE) bind factor Va with high affinity (K(d) = ∼10 nm) in the absence of phosphatidylserine (PS). These membranes support formation
Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders.
W H Kane et al.
Blood, 71(3), 539-555 (1988-03-01)
The C-terminus of tissue factor pathway inhibitor α is required for its interaction with factors V and Va.
M Ndonwi et al.
Journal of thrombosis and haemostasis : JTH, 10(9), 1944-1946 (2012-06-29)
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