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A2126

Sigma-Aldrich

Acetyl-β-methylcholine bromide

≥99%

Synonym(s):

Methacholine bromide

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About This Item

Linear Formula:
CH3CO2CH(CH3)CH2N(CH3)3Br
CAS Number:
333-31-3
Molecular Weight:
240.14
EC Number:
206-372-2
MDL number:
MFCD00011816
UNSPSC Code:
12352103
PubChem Substance ID:
24890626
NACRES:
NA.25

Quality Level

100

Assay

≥99%

form

powder

mp

147-149 °C (lit.)

storage temp.

−20°C

SMILES string

[Br-].CC(C[N+](C)(C)C)OC(C)=O

InChI

1S/C8H18NO2.BrH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1

InChI key

MMVPLEUBMWUYIB-UHFFFAOYSA-M

Gene Information

human ... CHRM3(1131)

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Application

Acetyl-β-methylcholine bromide (methylcholine bromide, methacholine bromide, Mch), a muscarinic acetylcholine receptor agonist, may be used in studies that involve the indentification, characterization and mechanism of action of muscarinic acetylcholine receptors. Mch may be used as a reference material in procedures used to detect or quantify its presence.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M J van der Schans et al.
Journal of chromatography. A, 735(1-2), 387-393 (1996-05-31)
Solutions of histamine and methacholine bromide in different matrices for diagnostic purposes were analyzed for stability and quality control using capillary electrophoresis. Histamine (2,[4-imidazolyl]ethylamine) [CAS No. 51-45-6] was determined using a 0.1 M Tris-borate buffer of pH 8.3 with 5.10(-5)
David C Hornigold et al.
British journal of pharmacology, 138(7), 1340-1350 (2003-04-25)
1. We have examined possible mechanisms of cross-talk between the G(q/11)-linked M(3) muscarinic acetylcholine (mACh) receptor and the G(i/o)-linked M(2) mACh receptor by stable receptor coexpression in Chinese hamster ovary (CHO) cells. A number of second messenger (cyclic AMP, Ins(1,4,5)P(3))
M Yamada et al.
Nature, 410(6825), 207-212 (2001-03-10)
Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved
Anyue Yin et al.
British journal of pharmacology, 175(16), 3394-3406 (2018-06-03)
Development of combination therapies has received significant interest in recent years. Previously, a two-receptor one-transducer (2R-1T) model was proposed to characterize drug interactions with two receptors that lead to the same phenotypic response through a common transducer pathway. We applied
John T Fisher et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(6), 711-713 (2004-02-24)
The presence of multiple muscarinic acetylcholine receptor (mAChR) subtypes in the heart and lung, combined with the lack of mAChR subtype-selective ligands, have complicated the task of identifying the mAChR subtypes mediating cardiac slowing (bradycardia) and airway narrowing (bronchoconstriction) due
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