475R-9

INSM1 (MRQ-70) Rabbit Monoclonal Antibody

clone MRQ-70, unconjugated, Cell Marque^™

• Synonym(s): Insulinoma-associated protein 1
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• Quality Level: 100; 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: MRQ-70, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (475R-94); vial of 0.1 mL concentrate Research Use Only (475R-94-RUO); vial of 0.5 mL concentrate (475R-95); vial of 1.0 mL concentrate (475R-96); vial of 1.0 mL concentrate Research Use Only (475R-96-RUO); vial of 1.0 mL pre-dilute Research Use Only (475R-97-RUO); vial of 1.0 mL pre-dilute ready-to-use (475R-97); vial of 7.0 mL pre-dilute ready-to-use (475R-98); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (475R-98-RUO)
• manufacturer/tradename: Cell Marque^™
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
• isotype: IgG
• control: pancreas
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear

Description

General description

Insulinoma-associated protein 1 (INSM1) is a transcriptional factor with a zinc finger DNA-binding domain that is involved in neuroendocrine cell differentiation as a transcriptional repressor¹. INSM1 expression has been observed during embryonic development in the cerebellum, spinal cord, olfactory epithelium, pancreas, and gastrointestinal tract^2-4; however, expression in healthy adult tissues is limited to neuroendocrine cells. INSM1 is over expressed in neuroendocrine neoplasms including carcinoids, small cell carcinomas, and neuroendocrine carcinomas. This helps in identification of neuroendocrine tumors and their distinction from other lesions, such as adenocarcinomas, which exhibit little to no INSM1 expression^5-6.

Quality

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

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Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable