Skip to Content
Merck
All Photos(1)

Key Documents

5.06239

Sigma-Aldrich

Bupropion Hydrochloride

Synonym(s):

Bupropion Hydrochloride, Dopamine and noradrenalin Transporter Inibitor, Bupropion

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C13H18ClNO · xHCl
CAS Number:
Molecular Weight:
239.74 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥99% (HPLC)

Quality Level

form

solid

potency

1.4 μM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: soluble

storage temp.

2-8°C

InChI

1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H

InChI key

HEYVINCGKDONRU-UHFFFAOYSA-N

General description

A non-selective inhibitor of dopamine and noradrenalin transporters (Ki = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC50 = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.

Biochem/physiol Actions

Primary Target
DAT/NET

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Budzynska, B. et al. 2011 Pharmacol. Rep.63, 71.

Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service