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Key Documents

A72405

Sigma-Aldrich

2-Amino-1-phenylethanol

98%

Synonym(s):

α-(Aminomethyl)benzyl alcohol, DL-β-Hydroxyphenethylamine, Phenylethanolamine

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About This Item

Linear Formula:
NH2CH2CH(OH)C6H5
CAS Number:
Molecular Weight:
137.18
Beilstein:
971222
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

98%

form

solid

bp

160 °C/17 mmHg (lit.)

mp

56-58 °C (lit.)

SMILES string

NCC(O)c1ccccc1

InChI

1S/C8H11NO/c9-6-8(10)7-4-2-1-3-5-7/h1-5,8,10H,6,9H2

InChI key

ULSIYEODSMZIPX-UHFFFAOYSA-N

Gene Information

human ... PNMT(5409)

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Related Categories

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Qian Wu et al.
Journal of medicinal chemistry, 48(23), 7243-7252 (2005-11-11)
The X-ray structure of human phenylethanolamine N-methyltransferase (hPNMT) complexed with its product, S-adenosyl-L-homocysteine (4), and the most potent inhibitor reported to date, SK&F 64139 (7), was used to identify the residues involved in inhibitor binding. Four of these residues, Val53
Christine L Gee et al.
Biochimica et biophysica acta, 1750(1), 82-92 (2005-05-17)
The crystal structure of human phenylethanolamine N-methyltransferase (hPNMT) reveals a disulfide-linked dimer, despite the presence of reducing agent in the crystallisation conditions. By removing the reducing agent, hPNMT crystals grow more rapidly and at lower protein concentrations. However, it was
M Landi et al.
Biochemical pharmacology, 44(4), 665-672 (1992-08-18)
[3H]Dihydroalprenolol ([3H]DHA) specific binding (determined by the difference in the presence and absence of 20 microM (-)isoprenaline) to rat colon membranes was saturable (Bmax = 39.6 fmol/mg protein), of high affinity (Kd = 0.87 nM) and stereospecific (IC50 330 and
Erkan Karakas et al.
Nature, 475(7355), 249-253 (2011-06-17)
Since it was discovered that the anti-hypertensive agent ifenprodil has neuroprotective activity through its effects on NMDA (N-methyl-D-aspartate) receptors, a determined effort has been made to understand the mechanism of action and to develop improved therapeutic compounds on the basis
K M Buller et al.
Neuropharmacology, 49(2), 230-242 (2005-07-05)
In opiate addicts or patients receiving morphine treatment, it has been reported that the immune system is often compromised. The mechanisms responsible for the adverse effects of opioids on responses to infection are not clear but it is possible that

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