900583

Li-Li Auxiliary

≥95%

• Synonym(s): N-(2-Cyanophenethyl)-4-nitrobenzenesulfonamide
• Empirical Formula (Hill Notation): C₁₅H₁₃N₃O₄S
• Molecular Weight: 331.35
• UNSPSC Code: 12352101

Properties

• Assay: ≥95%
• form: powder or crystals
• reaction suitability: reaction type: C-C Bond Formation; reagent type: catalyst; reagent type: ligand; reaction type: C-H Activation

Description

Application

Li-Li auxiliary assists the direct meta-C–H olefination and acetoxylation of benzoic acids through a nitrile-based sulfonamide template under mild conditions. The expansion of substrate scope regardless of substitution patterns and steric biases will enable the wide adoption of this protocol to the synthesis of drug molecules and natural products, of which benzoic acids are significant motifs.

Other Notes

Pd(II)-catalysed meta-C–H functionalizations of benzoic acid derivatives

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable