UC430

1′-Hydroxymidazolam

≥97% (HPLC), powder

• Synonym(s): 8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine
• Empirical Formula (Hill Notation): C₁₈H₁₃ClFN₃O
• CAS Number: 59468-90-5
• Molecular Weight: 341.77
• UNSPSC Code: 12161501
• PubChem Substance ID: 24724655
• NACRES: NA.77
• MDL number: MFCD00871458
• Form: powder

Properties

• Product Name: 1′-Hydroxymidazolam,
• form: powder
• Quality Segment: 200
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• color: white to off-white
• storage temp.: 2-8°C
• SMILES string: OCc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12
• InChI: 1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2
• InChI key: QHSMEGADRFZVNE-UHFFFAOYSA-N

Description

General description

1′-Hydroxymidazolam is the metabolite of midazolam.

Application

CYP3A4 metabolite of midazolam.

1′-Hydroxymidazolam (1′-OHMDZ) can be used for assessing Cyp3a11 enzyme activity as well as for pharmacokinetic (PK) study of midazolam.

Biochem/physiol Actions

1′-Hydroxymidazolam is the major hydroxylated metabolite of Midazolam (MDZ), forms due to rapid and extensive metabolization of MDZ by the CYP 450 3A isoenzymes in the liver. The product contributes to the pharmacological impact of MDZ.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)