SML2796
PVHD121
≥98% (HPLC)
Synonym(s):
α-(4-Methoxyphenyl)-α-methyl-4-quinazolinemethanol
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About This Item
Empirical Formula (Hill Notation):
C17H16N2O2
CAS Number:
Molecular Weight:
280.32
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC(C)(C1=NC=NC2=CC=CC=C21)C3=CC=C(C=C3)OC
InChI key
WGDUWVWCDNCAOT-UHFFFAOYSA-N
Biochem/physiol Actions
PVHD121 is potent antimitotic agent that binds to the colchicine site of tubulin. PVHD121 selectively inhibits microtubule formation at centrosomes during mitosis. It delays entry into mitosis causing long lasting mitotic arrest by activation of spindle checkpoint.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Kenta Kuroiwa et al.
ACS medicinal chemistry letters, 6(3), 287-291 (2015-03-31)
A quinazoline derivative PVHD121 (1a) was shown to have strong antiproliferative activity against various tumor-derived cell lines, including A549 (lung), NCI-H460 (lung), HCT116 (colon), MCF7 (breast), PC3 (prostate), and HeLa (cervical) cells with IC50 values from 0.1 to 0.3 μM.
Jun-Ichi Sawada et al.
Molecular pharmacology, 96(5), 609-618 (2019-09-01)
In the research field of tubulin-binding agents for the development of anticancer agents, hidden targets are emerging as a problem in understanding the exact mechanisms of actions. The quinazoline derivative 1-(4-methoxyphenyl)-1-(quinazolin-4-yl)ethan-1-ol (PVHD121) has anti-cell proliferative activity and inhibits tubulin polymerization
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