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SML2284

Sigma-Aldrich

Mito A iodide

≥98% (HPLC)

Synonym(s):

3-(4’-Azidobenzamido)-prop-1-yl]triphenylphosphonium iodide

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About This Item

Empirical Formula (Hill Notation):
C28H26IN4OP
Molecular Weight:
592.41
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=C(N=[N+]=[N-])C=C4.[I-]

InChI

1S/C28H25N4OP.HI/c29-32-31-24-19-17-23(18-20-24)28(33)30-21-10-22-34(25-11-4-1-5-12-25,26-13-6-2-7-14-26)27-15-8-3-9-16-27;/h1-9,11-20H,10,21-22H2;1H

InChI key

DMRSJCIHHULJSH-UHFFFAOYSA-N

Biochem/physiol Actions

MitoA is selective hydrogen sulfide (H2S) probe targeting mithchondria suitable for in vivo use. MitoA accumulates in mitochondria within tissues, where it is converted to MitoN by reaction with H2S. Both compounds are detected sensitively by LC-MS/MS.
selective hydrogen sulfide (H2S) probe targeting mithchondria suitable for in vivo use.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Sabine Arndt et al.
The Journal of biological chemistry, 292(19), 7761-7773 (2017-03-23)
Hydrogen sulfide (H2S) is produced endogenously in vivo and has multiple effects on signaling pathways and cell function. Mitochondria can be both an H2S source and sink, and many of the biological effects of H2S relate to its interactions with

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