HC-067047 has been used as a transient receptor potential cation channel subfamily V member 4 (TRPV4) inhibitor:
to study its effects on organoid formation and proliferation in human endometrial tissues[1]
to determine its effects on neuronal survival after intracerebral hemorrhage (ICH)[2]
to study its effects on TRPV4 regulation of angiotensin II receptor type 1 (AT1R) task, phosphorylation and β-arrestin recruitment in choroid plexus[3]
Biochem/physiol Actions
HC-067047 is a TRPV4 antagonist
HC-067047 is a potent, selective inhibitor of hTRPV4. The compound inhibits human, rat and mouse TRPV4 with IC50 values of 48, 133 and 17 nM, respectively. HC-067047 does not inhibit other TRPV isoforms at concentrations up to 5 μM. HC-067047 inhibits hERG channel and the menthol receptor TRPM8 with IC50 values of 370 and 780 nM, respectively.
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