SAB4504108

Anti-phospho-TIP60 (pSer⁸⁶) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): KAT5, Lysine acetyltransferase 5
• UNSPSC Code: 12352203
• NACRES: NA.43

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 58 kDa
• species reactivity: rat, mouse, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:40000; western blot: 1:500-1:1000
• NCBI accession no.: Q92993
• UniProt accession no.: Q92993
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer86)
• Gene Information: human ... KAT5(10524)

Description

General description

The TIP60 (HIV1 (human immunodeficiency virus 1)-TAT interactive protein) gene is mapped to human chromosome 11q13.1. It is ubiquitously expressed and evolutionarily conserved. The encoded protein, Tip60 belongs to the MYST (Moz, Ybf2/Sas3, Sas2 and TIP60) family.

Immunogen

The antiserum was produced against synthesized peptide derived from human TIP60 around the phosphorylation site of Ser86.

Immunogen Range: 52-101

Application

TIP60 (HIV1-TATinteractive protein) possess acetyltransferase activity and participates in chromatin remodeling and DNA damage repair. TIP60 is involved in protein stabilization and protein function modulation. The presence of chromodomain and MYST domain in its structure enables acetylation of both histone and non-histone proteins. TIP60 in association with androgenic receptors and transcription factors can control gene transcription and cell cycle process. TIP60 mediates p53 action to induce apoptosis. TIP60 inhibits Hepatitis B virus infection. TIP60 acts as a haploinsufficient tumor suppressor.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable