SAB2500950
Anti-SLC6A4/5HTT/SERT antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-HGNC:11050, Anti-SERT
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About This Item
Pricing and availability is not currently available.
Recommended Products
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC6A4(6532)
General description
Solute carrier family 6 member 4 (SLC6A4), also known as 5-hydroxytryptamine transporter (5-HTT), is an integral membrane protein, encoded by the gene mapped to human chromosome 17q11.2. The encoded protein is a member of SLC6 gene family and is mainly expressed in brain and blood cells.
Immunogen
Peptide with sequence C-LHQGERETWGK from the internal region of the protein sequence according to NP_001036.1.
Application
Anti-SLC6A4/5HTT/SERT antibody produced in goat has been used in immunolabelling and Western blotting.
Biochem/physiol Actions
Solute carrier family 6 member 4 (SLC6A4) catalyzes the transport of neurotransmitter serotonin from the synaptic space into presynaptic neurons. It also plays a vital role in mood and anxiety regulation. Mutation on the gene might alter the expression of serotonin (5HT) in the synaptic cleft, which ultimately leads to schizophrenia. Allelic variations in the gene increase the risk of susceptibility to autism and rigid-compulsive behaviors.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE e4
Nadia P
Pathology (2010)
Nadia Postupna et al.
The American journal of pathology, 187(4), 884-895 (2017-02-19)
Cognitive impairment in older individuals is a complex trait that in population-based studies most commonly derives from an individually varying mixture of Alzheimer disease, Lewy body disease, and vascular brain injury. We investigated the molecular composition of synaptic particles from
Epigenetic Changes of Serotonin Transporter in the Patients with Alcohol Dependence: Methylation of an Serotonin Transporter Promoter CpG Island
Byung-Yang Park
Psychiatry Investigation (2011)
Allelic Heterogeneity at the Serotonin Transporter Locus (SLC6A4) Confers Susceptibility to Autism and Rigid-Compulsive Behaviors
James S
Academic Journal of Interdisciplinary Studies (2005)
miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells
Pablo R
The International Journal of Neuropsychopharmacology (2013)
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