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S8758

Sigma-Aldrich

N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin

protease substrate, ≥98%, powder

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About This Item

Empirical Formula (Hill Notation):
C29H32N4O8
CAS Number:
71973-79-0
Molecular Weight:
564.59
MDL number:
MFCD00038448
UNSPSC Code:
12352204
PubChem Substance ID:
24899814
NACRES:
NA.32

Product Name

N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin, protease substrate

Assay

≥98%

form

powder

solubility

50% acetic acid: 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC(NC(=O)CCC(O)=O)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C29H32N4O8/c1-16-13-26(37)41-23-15-20(9-10-21(16)23)32-29(40)22(14-19-7-5-4-6-8-19)33-28(39)18(3)31-27(38)17(2)30-24(34)11-12-25(35)36/h4-10,13,15,17-18,22H,11-12,14H2,1-3H3,(H,30,34)(H,31,38)(H,32,40)(H,33,39)(H,35,36)

InChI key

HHPVJKZZYOXPLH-UHFFFAOYSA-N

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000296073
SLCQ4029
SLCR1949
SLCF9544
SLBJ4202V

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Naoto Watamura et al.
Molecular psychiatry (2021-11-06)
Alzheimer's disease (AD) is characterized by the deposition of amyloid β peptide (Aβ) in the brain. The neuropeptide somatostatin (SST) regulates Aβ catabolism by enhancing neprilysin (NEP)-catalyzed proteolytic degradation. However, the mechanism by which SST regulates NEP activity remains unclear.
Christiane Ott et al.
Redox biology, 46, 102106-102106 (2021-08-30)
Removal of moderately oxidized proteins is mainly carried out by the proteasome, while highly modified proteins are no longer degradable. However, in the case of proteins modified by nitration of tyrosine residues to 3-nitrotyrosine (NO2Y), the role of the proteasome
Maria J Xavier et al.
Animals : an open access journal from MDPI, 11(6) (2021-07-03)
The larval stage is highly prone to stress due to the ontogenetic and metabolic alterations occurring in fish. Curcumin inclusion in diets has been shown to improve growth by modulating oxidative status, immune response, and/or feed digestibility in several fish
Fadi Rofo et al.
Theranostics, 11(2), 789-804 (2021-01-05)
Background: Aggregation of the amyloid-beta (Aβ) peptide is one of the main neuropathological events in Alzheimer's disease (AD). Neprilysin is the major enzyme degrading Aβ, with its activity enhanced by the neuropeptide somatostatin (SST). SST levels are decreased in the

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