Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

PZ0231

Sigma-Aldrich

PF-06462894

≥98% (HPLC)

Synonym(s):

6(R)-(2,2-Dimethyl-propyl)-2-(pyridin-2-ylmethoxy)-6,7-dihydro-9H-pyrimido[2,1-c][1,4]oxazin-4-one

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C18H23N3O3
CAS Number:
1622291-66-0
Molecular Weight:
329.39
MDL number:
MFCD28137683
UNSPSC Code:
51111800
PubChem Substance ID:
329823782
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

O=C1C=C(OCC2=NC=CC=C2)N=C3COC[C@@H](CC(C)(C)C)N31

InChI

1S/C18H23N3O3/c1-18(2,3)9-14-11-23-12-15-20-16(8-17(22)21(14)15)24-10-13-6-4-5-7-19-13/h4-8,14H,9-12H2,1-3H3/t14-/m1/s1

InChI key

QDIYOEYPJWXMRN-CQSZACIVSA-N

Biochem/physiol Actions

PF-06462894 is a muscarinic metabotropic receptor mGluR5 ligand.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Gopinath S Palanisamy et al.
Toxicologic pathology, 43(7), 995-1003 (2015-06-11)
Three orally administered metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulators caused skin lesions consistent with delayed type-IV hypersensitivity in cynomolgus macaques in 2- and 12-week toxicity studies. Several monkeys developed macroscopic skin lesions in multiple locations after 8 to

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service