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MAK014

Sigma-Aldrich

Glucose-6-Phosphate Assay Kit

sufficient for 100 colorimetric tests

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
Pricing and availability is not currently available.

usage

sufficient for 100 colorimetric tests

detection method

colorimetric

relevant disease(s)

hematological disorder

storage temp.

−20°C

General description

Glucose 6-phosphate (G6P) is a key metabolic intermediate that enters either metabolic pathways or storage. G6P is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the beginning of both glycolysis and the pentose phosphate pathways. It also can be stored as glycogen when blood glucose levels are high.[1]

Application

Glucose-6-phosphate assay kit has been used in:

  • glucose 6-phosphate (G6P) assay[2]
  • quantification of glucose-6-phosphate (G6P)[3][4][5] and fructose-6-phosphate (F6P)[3]
  • metabolite analysis[6]

Suitability

Suitable for quantifying Glucose-6-Phosphate in a variety of samples.

Principle

G6P is utilized by Glucose-6-phosphate dehydrogenase to generate reducing equivalents in the form of NADPH. This is particularly important in red blood cells where a G6PDH deficiency leads to hemolytic anemia. G6P is determined by an enzyme assay, which results in a colorimetric (450 nm) product, proportional to the G6P present. Typical sensitivities of detection are between 1-30 nmoles.

replaced by

Product No.
Description
Pricing

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H314,H334

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
8J08K06570
8D21K06570
7K07K06570
7D12K06570
6H06K06570

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Reciprocal Control of Anaplerotic Phosphoenolpyruvate Carboxylase by in Vivo Monoubiquitination and Phosphorylation in Developing Proteoid Roots of Phosphate-Deficient Harsh Hakea
Shane M W, et al.
Plant Physiology, 112-112 (2013)
Renal Disease in Type I Glycogen Storage Disease
Richard P L, et al.
Genetic Diseases of the Kidney (2009)
MiR-182 promotes glucose metabolism by upregulating hypoxia-inducible factor 1a in NSCLC cells
Mingliang W, et al.
Biochemical and Biophysical Research Communications, 504(2), 400-405 (2018)
Saixiang Feng et al.
Veterinary research, 51(1), 97-97 (2020-08-02)
Lipooligosaccharides (LOSs) are virulence determinants of Glaesserella parasuis, a pathogen of the respiratory tract of pigs. We previously reported that disruption of the galU or galE gene in G. parasuis results in increased sensitivity to porcine serum, indicating that the
Over expression of hyaluronan promotes progression of HCC via CD44-mediated pyruvate kinase M2 nuclear translocation
Li J H, et al.
American Journal of Cancer Research, 6(2), 509-521 (2016)
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