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I7016

Sigma-Aldrich

H-7 dihydrochloride

≥98% (HPLC)

Synonym(s):

1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride, Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H17N3O2S · 2HCl
CAS Number:
108930-17-2
Molecular Weight:
364.29
Beilstein:
5840763
MDL number:
MFCD00036961
UNSPSC Code:
12352200
PubChem Substance ID:
24278496
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

solubility

H2O: 20 mg/mL

storage temp.

2-8°C

SMILES string

Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23

InChI

1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H

InChI key

OARGPFMFRLLKPF-UHFFFAOYSA-N

Gene Information

human ... PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584)

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General description

H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β).

Application

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

Biochem/physiol Actions

Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.

Caution

Light sensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Endotoxin in Health and Disease, 289-298 (1999)
Molecular diversity of cell-matrix adhesions
Zamir E, et al.
Journal of Cell Science, 112(11), 1655-1669 (1999)
A new dimension in retrograde flow: centripetal movement of engulfed particles
Caspi A, et al.
Biophysical Journal, 81(4), 1990-2000 (2001)
Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV)
Ito M, et al.
Antiviral Research, 10(6), 289-298 (1988)
Christopher J Groten et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2747-2765 (2015-02-13)
It is unknown whether neurons can dynamically control the capacity for secretion by promptly changing the number of plasma membrane voltage-gated Ca(2+) channels. To address this, we studied peptide release from the bag cell neurons of Aplysia californica, which initiate

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