H8636
Anti-Haptoglobin antibody produced in rabbit
IgG fraction of antiserum, lyophilized powder
Synonym(s):
Anti-BP, Anti-HP2ALPHA2, Anti-HPA1S
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
packaging
vial of 2 mL lyophilized antiserum
technique(s)
indirect ELISA: 1:30,000
UniProt accession no.
application(s)
research pathology
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... HP(3240)
General description
Haptoglobin (HP) is encoded by the gene mapped to human chromosome 16q22.2. There are two splice variants of the gene namely, HP1 and HP2.
Immunogen
Human haptoglobin
Application
Anti-Haptoglobin antibody is suitable for use in Ouchterlony double diffusion (1:16) and immunoelectrophoresis.
Anti-Haptoglobin antibody produced in rabbit has been used in immunohistochemistry and western blotting.
Biochem/physiol Actions
Haptoglobin is an antioxidant protein that binds with hemoglobin. Haptoglobin primarily functions to inhibit oxidative damage induced by hemoglobin. Alterations in haptoglobin have been associated with the risk of diabetic vascular disorders such as retinopathy, nephropathy and cardiovascular diseases . Anti-Haptoglobin antibody is specific for haptoglobin in humans.
Physical form
Lyophilized from 0.01 M phosphate buffered saline, pH 7.2
Reconstitution
Reconstitute with 2 ml deionized water.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Megan E McCarthy et al.
Placenta, 62, 50-57 (2018-02-07)
Haptoglobin (Hp) has key immunoregulatory roles that vary with phenotype (Hp1-1, Hp2-1, Hp2-2). Cord blood Hp expression is switched-off in the normal fetus. We hypothesized that in the setting of fetal inflammation placenta becomes inundated with Hp of fetal origin
Identification of haptoglobin switch-on status in archived placental specimens indicates antenatal exposure to inflammation and potential participation of the fetus in triggering preterm birth
McCarthy M, et al.
Placenta, 62(2), 50-57 (2018)
Hyewon Choi et al.
Frontiers in oncology, 13, 1183442-1183442 (2023-05-12)
Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery. Serologic cancer biomarkers have been used in clinical practice, but their low specificity and
Vivekananda Shetty et al.
Clinical proteomics, 9(1), 10-10 (2012-08-04)
In approximately 80% of patients, ovarian cancer is diagnosed when the patient is already in the advanced stages of the disease. CA125 is currently used as the marker for ovarian cancer; however, it lacks specificity and sensitivity for detecting early
Hagit Goldenstein et al.
Pharmacological research, 66(1), 1-6 (2012-04-03)
Haptoglobin (Hp) is a hemoglobin (Hb) binding protein whose major function is to prevent heme-iron mediated oxidation. The polymorphic nature of the Hp gene results in varying levels of antioxidant function associated with the protein products. Multiple clinical studies have
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