C6348
Monoclonal Anti-CXCR2 (IL-8 RB) antibody produced in mouse
clone 48311.211, purified immunoglobulin, lyophilized powder
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About This Item
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
48311.211, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
flow cytometry: suitable
neutralization: suitable
isotype
IgG2a
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IL8RB(3579)
mouse ... Il8rb(12765)
General description
The antibody will neutralize human cell surface CXCR-2 mediated-myloperoxidase release from human granulocytes induced by GROα. It will not block myeloperoxidase release induced by IL-8. The antibody reacts with human CXCR-2 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR-1.
Immunogen
human CXCR2 transfected NSO mouse myeloma cells.
Biochem/physiol Actions
CXCR2 is a G protein-coupled receptor that binds IL-8 with high affinity. It mediates migration of neutrophils to the sites of inflammation. It also binds CXCL1 and stimulates growth of melanomas.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Preparation Note
Purified using protein G.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Snjezana Zaja-Milatovic et al.
Histology and histopathology, 23(11), 1399-1407 (2008-09-12)
Wound healing requires a complex series of reactions and interactions among cells and their mediators, resulting in an overlapping series of events including coagulation, inflammation, epithelialization, formation of granulation tissue, matrix and scar formation. Cytokines and chemokines promote inflammation, angiogenesis
Michael J Robertson
Journal of leukocyte biology, 71(2), 173-183 (2002-01-31)
Natural killer (NK) cells participate in innate and adaptive immune responses to obligate intracellular pathogens and malignant tumors. Two major NK cell subsets have been identified in humans: CD56(dim) CD16+ and CD56(bright) CD16-. Resting CD56(dim) CD16+ NK cells express CXCR1
Chia-Yuan Hsieh et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3693-3703 (2014-08-31)
IFN-γ mediates chemically induced skin inflammation; however, the mechanism by which IFN-γ-producing cells are recruited to the sites of inflammation remains undefined. Secretion of macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, from damaged cells may promote immune cell recruitment.
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