This product may be stored at room temperature for both, short and long term periods.
94956
Vinylcyclohexene dioxide
purum, suitable for electron microscopy, mixture of isomers, ≥96.0% (GC)
Synonym(s):
4-vinyl-1-cyclohexene diepoxide, 1,2-Epoxy-4-epoxyethylcyclohexane, 3-Epoxyethyl-7-oxabicyclo[4.1.0]heptane
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About This Item
Empirical Formula (Hill Notation):
C8H12O2
CAS Number:
Molecular Weight:
140.18
Beilstein:
106071
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.25
Pricing and availability is not currently available.
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Quality Level
grade
purum
Assay
≥96.0% (GC)
form
liquid
technique(s)
electron microscopy: suitable
refractive index
n20/D 1.477 (lit.)
n20/D 1.479
bp
230-232 °C (lit.)
density
1.094 g/mL at 25 °C (lit.)
SMILES string
C1CC2OC2CC1C3CO3
InChI
1S/C8H12O2/c1-2-6-7(10-6)3-5(1)8-4-9-8/h5-8H,1-4H2
InChI key
OECTYKWYRCHAKR-UHFFFAOYSA-N
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Application
Vinylcyclohexene dioxide (VCD) may be used to study and understand its effect on ovarian follicles and effects on epithelial differentiation.
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Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
Flash Point(F)
224.6 °F - closed cup
Flash Point(C)
107 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Melissa J Romero-Aleshire et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 297(3), R587-R592 (2009-05-15)
Factors comprising the metabolic syndrome occur with increased incidence in postmenopausal women. To investigate the effects of ovarian failure on the progression of the metabolic syndrome, female B(6)C(3)F(1) mice were treated with 4-vinylcyclohexene diepoxide (VCD) and fed a high-fat (HF)
Aileen F Keating et al.
Biology of reproduction, 84(4), 743-751 (2010-11-16)
4-Vinylcyclohexene diepoxide (VCD), an occupational chemical that specifically destroys primordial and small primary follicles in the ovaries of rats and mice, is thought to target an oocyte-expressed tyrosine kinase receptor, Kit. This study compared the temporal effect of VCD on
Lida P Hariri et al.
Cancer biology & therapy, 10(5), 438-447 (2010-11-26)
Determining if an ovarian mass is benign or malignant is an ongoing clinical challenge. The development of reliable animal models provides means to evaluate new diagnostic tools to more accurately determine if an ovary has benign or malignant features. Although
Tracey A Van Kempen et al.
Brain research, 1379, 176-187 (2011-01-08)
Current rodent models of menopause fail to adequately recapitulate the menopause transition. The intact aging model fails to achieve very low estrogen levels, and the ovariectomy model lacks a perimenopause phase. A new rodent model of accelerated ovarian failure (AOF)
P B Hoyer et al.
Toxicologic pathology, 29(1), 91-99 (2001-02-24)
Female mammals are born with a finite number of ovarian primordial follicles that cannot be regenerated; thus, chemicals that destroy oocytes contained in these follicles can produce premature ovarian failure (early menopuase in women). Exposure of women to known ovotoxicants
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How should VCD be stored, for short term and long term?
1 answer-
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What is the concentration of VCD #94956 ( mg / ml)?
1 answer-
This product is supplied as a neat or pure liquid with a density of 1.094 g/mL and a molecular weight of 140.18 g/mol. The minimum purity is 96%, thus the molarity will vary slightly from lot to lot. The molarity can range from 7.5 M (96%) to 7.8 M (100%). The lot specific purity is reported on the Certificate of Analysis. Please see the link below to review a sample Certificate: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/94956-BULKBCCJ4415.pdf
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¿En qué está disuelto este producto (94956): aceite de sesamo, Alcohol, DMSO? . Tengo que usarlo más diluido para inyectar en ratones. Gracias
1 answer-
Product 94956 is a neat liquid of Vinylcyclohexene dioxide (VCD) at room temperature. According to the following scientific article, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703138/, VCD was either prepared for intramuscular injection with cottonseed oil, or prepared with sesame oil for intraperitoneal injection.
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