Skip to Content
Merck
All Photos(3)

Key Documents

84510

Sigma-Aldrich

Saponin

greener alternative

used as non-ionic surfactant

Synonym(s):

glycosides, saponins

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

CAS Number:
8047-15-2
EC Number:
232-462-6
MDL number:
MFCD00081981
UNSPSC Code:
12161900
NACRES:
NA.25
Pricing and availability is not currently available.

biological source

plant (Quillaya)

Quality Level

300

form

powder

composition

Sapogenin, 8-25%

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

HPLC: suitable
protein quantification: suitable

impurities

≤20% sulphated ash

CMC

0.001-0.01%

solubility

water: 1 g/10 mL, clear to hazy, yellow to brown

density

1.015-1.020 g/mL at 20 °C (5% in H2O)(lit.)

greener alternative category

Aligned

SMILES string

C[C@]1(CCC23COC4([C@H]2C1)CC[C@@H]5[C@]6(CC[C@@H](C(C6CC[C@]5([C@@]4(C[C@H]3O)C)C)(C)C)O[C@H]7[C@@H]([C@H]([C@H](CO7)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)O[C@@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)C)C=O

InChI

1S/C58H94O27/c1-52(2)29-7-11-55(5)30(8-12-58-31-15-53(3,22-62)13-14-57(31,23-77-58)32(64)16-56(55,58)6)54(29,4)10-9-33(52)82-50-46(85-51-45(40(71)37(68)27(19-61)80-51)84-49-43(74)39(70)36(67)26(18-60)79-49)44(83-48-42(73)38(69)35(66)25(17-59)78-48)28(21-76-50)81-47-41(72)34(65)24(63)20-75-47/h22,24-51,59-61,63-74H,7-21,23H2,1-6H3/t24-,25-,26-,27-,28+,29?,30-,31+,32-,33+,34+,35-,36-,37-,38+,39+,40+,41-,42-,43-,44+,45-,46-,47+,48-,49-,50+,51+,53-,54+,55-,56+,57?,58?/m1/s1

InChI key

MAEBCGDGGATMSC-OSHGGGOQSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Canonical SMILES: CC1(C2CCC3(C(C2(CCC1OC4C(C(C(CO4)OC5C(C(C(CO5)O)O)O)OC6C(C(C(C(O6)CO)O)O)O)OC7C(C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CCC91C3(CC(C2(C9CC(CC2)(C)C=O)CO1)O)C)C)C
Saponins, belonging to the class of steroid or triterpenoid glycosides, are widely distributed in plants, marine animals, and certain bacteria, serving as crucial compounds in various research fields, including biochemical, cell biology, and beyond. These amphipathic glycosides exhibit soap-like foaming in aqueous solutions due to their distinctive structure, featuring hydrophilic glycoside moieties combined with a lipophilic triterpene derivative.

Beyond their structural uniqueness, saponins play essential roles in biochemical processes, acting as secondary metabolites that facilitate protein penetration through cell membranes. Studies indicate their amphipathic nature and potential as hemolytic agents, contributing to their utility in immunoassays by stimulating the Th1 immune response and cytotoxic T-lymphocyte production. In cell biology, saponins find applications as nonionic surfactants, influencing cellular processes and interactions.

Moreover, saponins serve as promising components in vaccine research, functioning as adjuvants that can activate the mammalian immune system. This property, combined with their ability to solubilize low-density lipoproteins and regulate cholesterol concentration in micelles, makes saponins versatile and valuable in multidisciplinary research areas, including biochemical and cell biology research.
We are committed to bringing you greener alternative products, which adhere to one or more of the 12 Principles of Green Chemistry. This product is Bio-based and thus aligns with ″Use of Renewable Feedstocks″.

Application

Glycoside used as a nonionic sufactant and adjuvant in vaccine development.
Saponin has been used:
  • as a wetting agent to study its effects on the floatability of six plastics
  • to permeabilize washed neutrophils for immunofluorescence
  • as a supplement in phosphate buffer saline (PBS) for immunocytochemistry

Biochem/physiol Actions

Saponins are nonionic surfactant that forms oil-in-water emulsions and acts as a protective colloid. They are used for the direct determination of metals in milk by flame atomic absorption spectrophotometry.

Features and Benefits

  • Suitable for Biochemical and Cell Biology research
  • Can be used with HPLC and Protein Quantification
  • High purity product for research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCV7670
MKCV3132
MKCV7669
MKCS9147
BCCB4938

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Olusola Olalekan Elekofehinti
Pathophysiology : the official journal of the International Society for Pathophysiology, 22(2), 95-103 (2015-03-11)
Diabetes mellitus (DM) represents a global health problem. It is the most common of the endocrine disorders and is characterized by chronic hyperglycemia due to relative or absolute lack of insulin secretion or insulin actions. According to the World Health
Sarah Costers et al.
Veterinary research, 40(5), 46-46 (2009-05-19)
The replication of porcine reproductive and respiratory syndrome virus (PRRSV) in lungs and lymphoid tissues of PRRSV-infected pigs is already strongly reduced before the appearance of neutralizing antibodies, indicating that other immune mechanisms are involved in eliminating PRRSV at those
Patcharaporn Tippayawat et al.
PLoS neglected tropical diseases, 3(4), e407-e407 (2009-04-09)
Infection with the Gram-negative bacterium Burkholderia pseudomallei is an important cause of community-acquired lethal sepsis in endemic regions in southeast Asia and northern Australia and is increasingly reported in other tropical areas. In animal models, production of interferon-gamma (IFN-gamma) is
Julia Cuthbert et al.
Polymers, 11(5) (2019-05-01)
Degradable polymers are crucial in order to reduce plastic environmental pollution and waste accumulation. In this paper, a natural product, tannic acid was modified to be used as a polymer star core. The tannic acid was modified with atom transfer
Shumin Tan et al.
PLoS pathogens, 5(5), e1000407-e1000407 (2009-05-05)
Helicobacter pylori (Hp) intimately interacts with the gastric epithelial surface and translocates the virulence factor CagA into host cells in a contact-dependent manner. To study how Hp benefits from interacting with the cell surface, we developed live-cell microscopy methods to
View All Related Papers

Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. what is the molecular weight of product: 84510

    1 answer

    1. The molecular weight of this product is not determined. However, historical data suggests this material contains saponins with a molecular weight range of 1400-2000 Daltons. The actual molecular weight is dependent upon the number of sugar residues attached to the core.

      Helpful?

  4. Qual è la composizione del prodotto, o almeno da dove è derivato?

    1 answer

    1. This product is saponin from quillaya bark. This triterpene saponine consists of Quillaicacid (structure kindly find enclosed below) combined with saccharide chains. Hydrolysis yields Quillaic acid, glacturonic acid, glucuronic acid and galactose (from Roempp's Chemical Encyclopedia).

      Please see the sample Certificate of Origin for more information:
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COO/Q12/84510-BULKSLCF7866.pdf

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service