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Sigma-Aldrich

Brij® L4

average Mn ~362

Synonym(s):

Polyethylene glycol dodecyl ether, Polyoxyethylene (4) lauryl ether

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About This Item

Linear Formula:
(C20H42O5)n
CAS Number:
9002-92-0
MDL number:
MFCD00043063
UNSPSC Code:
12161900
PubChem Substance ID:
24854130
NACRES:
NA.21
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description

non-ionic

Quality Level

200

mol wt

average Mn ~362

refractive index

n20/D 1.451 (lit.)

density

0.95 g/mL at 25 °C (lit.)

HLB

9

SMILES string

CCCCCCCCCCCCOCCOCCOCCOCCO

InChI

1S/C20H42O5/c1-2-3-4-5-6-7-8-9-10-11-13-22-15-17-24-19-20-25-18-16-23-14-12-21/h21H,2-20H2,1H3

InChI key

WPMWEFXCIYCJSA-UHFFFAOYSA-N

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General description

Brij® L4 is a non-ionic surfactant. It comprises an alkyl (C12) tail attached to an oxyethylene headgroup.[1]

Application

Brij® L4 has been used:
  • as a surfactant for the synthesis of copper(I) oxide (Cu2O) spherical nanoparticles using a microemulsion technique[2]
  • as a non-ionic surfactant for preparing reverse micelles to synthesize Pt3Co alloy nanoparticles[3]
  • as a surfactant to enhance the efficiency of interfacial coupling of hydrophobic materials and to make hydrogel[4]

Biochem/physiol Actions

Brij® L4 exhibits amphiphilic properties.[5] Brij L4 contains hydrophobic and hydrophilic regions that can form micelles and disperse hydrophobic drugs into the core of micelles. This in turn enhances drug solubility. Brij L4 also elicits a strong inhibitory effect against breast cancer resistance protein (BCRP) mediated drug efflux.[5] It inhibits Taq adsorption better when compared to other commonly used surfactants. Brij L4 supports droplet polymerase chain reaction (PCR) in picoliter reaction volumes at standard Taq concentrations.[1]

Legal Information

Brij is a registered trademark of Croda International PLC

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H315,H319,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV8516
MKCQ7698
MKCL6849
MKCK4613
MKCH6859

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Synthesis of Pt3Co alloy nanocatalyst via reverse micelle for oxygen reduction reaction in PEMFCs
Liu Z, et al.
Topics in Catalysis, 49(3), 241-250 (2008)
Copper (i) oxide nanoparticle-mediated C-C couplings for synthesis of polyphenylenediethynylenes: Evidence for a homogeneous catalytic pathway
Pary FF, et al.
Catalysis Science & Technology, 11(7), 2414-2421 (2021)
Paul Le Floch et al.
ACS applied materials & interfaces, 9(30), 25542-25552 (2017-07-12)
The emergence of stretchable electronics and its potential integration with textiles have highlighted a challenge: Textiles are wearable and washable, but electronic devices are not. Many stretchable conductors have been developed to enable wearable active textiles, but little has been
N Shadid et al.
The British journal of surgery, 99(8), 1062-1070 (2012-05-26)
New minimally invasive treatment modalities, such as ultrasound-guided foam sclerotherapy (UGFS), are becoming more popular. In a multicentre randomized controlled non-inferiority trial, the effectiveness and costs of UGFS and surgery for treatment of the incompetent great saphenous vein (GSV) were
Jacomina W van den Esschert et al.
Annals of surgery, 255(2), 311-318 (2012-01-14)
To compare the safety and hypertrophy response after portal vein embolization (PVE) using 2 absorbable and 3 permanent embolization materials. Portal vein embolization is used to increase future remnant liver volume preoperatively. Application of temporary, absorbable embolization materials could be
View All Related Papers

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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