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878112C

Avanti

C16-18:1 PC

Avanti Research™ - A Croda Brand 878112C

Synonym(s):

1-O-hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C42H84NO7P
CAS Number:
95403-34-2
Molecular Weight:
746.09
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 1 mL (878112C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 878112C

concentration

5 mg/mL (878112C-5mg)

lipid type

phosphoglycerides
bioactive lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COCCCCCCCCCCCCCCCC)=O

General description

C16-18:1 PC, also referred as 1-O-hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine (HOPC), is a platelet activating factor. It belongs to the class of bioactive lipids. HOPC is a mono-ether PC containing ester-linked 18:1 chain (oleoyl) at the sn-2 position and an ether-linked 16:0 chain (hexadecyl) at the sn-1 position.

Application

C16-18:1 PC or 1-O-hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine may be used: as a lipid standard for quantification of glycerophosphocholine by liquid chromatography–mass spectrometry (LC–MS), in preparation of phospholipid vesicles, as a substrate to study the substrate specificity of phospholipase B/lipase (PLB/LIP) in the presence and absence of deoxycholate (DOC).

Biochem/physiol Actions

Platelet-activating factor (PAF) acts as a lipid mediator and is involved in various inflammatory diseases.

Packaging

5 mL Clear Glass Sealed Ampule (878112C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Certificates of Analysis (COA)

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H Tojo et al.
The Journal of biological chemistry, 273(4), 2214-2221 (1998-01-27)
A brush border membrane-associated phospholipase B/lipase was solubilized from the distal two-thirds of rat small intestine by autolysis during storage at -35 degrees C over 1 month, and then the enzyme was purified to homogeneity and characterized enzymatically and structurally.
Matts Nylund et al.
Biochimica et biophysica acta, 1758(6), 807-812 (2006-06-17)
The glycolipid transfer protein (GLTP)-mediated movement of galactosylceramide from model membrane donor vesicles to acceptor vesicles is sensitive to the membrane environment surrounding the glycolipid. GLTP can catalyze the transfer of a fluorescently labeled GSL, anthrylvinyl-galactosylceramide (AV-GalCer), from vesicles composed
Andrey B Imbs et al.
PloS one, 14(4), e0215759-e0215759 (2019-04-30)
To expand our knowledge of lipid and fatty acid (FA) biosynthesis in marine cnidarians, polar lipidomes of hydrocorals were studied for the first time and then compared with those of soft corals from tropical and boreal regions. The structure and
Ernst R Werner et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(14), 7792-7798 (2020-03-27)
A significant fraction of the glycerophospholipids in the human body is composed of plasmalogens, particularly in the brain, cardiac, and immune cell membranes. A decline in these lipids has been observed in such diseases as Alzheimer's and chronic obstructive pulmonary
Akira Sato et al.
European journal of pharmacology, 745, 46-51 (2014-12-03)
Platelet-activating factor (PAF) is a potent lipid mediator that is implicated in numerous inflammatory diseases. C-reactive protein (CRP) is an acute-phase plasma protein that increases rapidly and dramatically in response to inflammation. In this study, we investigated the effect of
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