SPDP-dPEG36-NHS ester is an amphiphilic, water-soluble PEGylation reagent that is designed to crosslink amines and free thiols. SPDP (also referred to as orthopyridyl disulfide, or OPSS) reacts with sulfhydryl groups to form disulfide bonds. The N-hydroxysuccinimidyl (NHS) ester reacts with free amines to form amide bonds. The single molecular weight, discrete chain length polyethylene glycol (dPEG) chain is 115 atoms (137.8 Å) long. SPDP-dPEG36-NHS ester is used like SPDP and its related hydrophobic products. However, the water-soluble dPEG product prevents hydrophobicity-triggered precipitation of compounds to which it is conjugated. SPDP-dPEG36-NHS ester is a monodisperse equivalent of the polymeric PEG1500.
Legal Information
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Even when treated with aggressive current therapies, most patients with glioblastoma survive less than two years. Rapid tumor growth, an invasive nature, and the blood-brain barrier, which limits the penetration of large molecules into the brain, all contribute to the
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