Z2626

Zaragozic acid A trisodium salt

from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor

• Synonym(s): L-694,599, Squalestatin
• Empirical Formula (Hill Notation): C₃₅H₄₃O₁₄Na₃
• CAS Number: 144541-82-2
• Molecular Weight: 756.68
• MDL number: MFCD03788025
• UNSPSC Code: 12352106
• NACRES: NA.77

Properties

• product name: Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial
• biological source: microbial
• Quality Level: 200
• Assay: ≥95% (HPLC)
• form: lyophilized powder
• solubility: DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• shipped in: wet ice
• storage temp.: −20°C

Description

Application

Zaragozic acid A trisodium salt has been used as:

• a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
• a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
• a cholesterol synthesis inhibitor in T cells

Biochem/physiol Actions

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

Legal Information

Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves