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X4879

Sigma-Aldrich

Xaliproden hydrochloride

≥97% (HPLC), solid

Synonym(s):

1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine hydrochloride, SR-57746A

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About This Item

Empirical Formula (Hill Notation):
C24H22F3N · HCl
CAS Number:
90494-79-4
Molecular Weight:
417.89
MDL number:
MFCD00896209
UNSPSC Code:
12352200
PubChem Substance ID:
329830807
NACRES:
NA.77

Quality Level

100

Assay

≥97% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: ≥5 mg/mL

originator

Sanofi Aventis

storage temp.

2-8°C

SMILES string

Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2

InChI

1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H

InChI key

WVHBEIJGAINUBW-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350)

Biochem/physiol Actions

5-HT1A serotonin receptor agonist; neuroprotectant

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P Murali Doraiswamy et al.
Expert opinion on pharmacotherapy, 7(1), 1-10 (2005-12-24)
This review examines key pharmacological strategies that have been clinically studied for the primary or secondary prevention of Alzheimer's disease. Much information (neuropsychological, genetic and imaging) is already available to characterise an individual's risk for developing Alzheimer's disease. However, regulatory
J P Terranova et al.
Neuroscience letters, 213(2), 79-82 (1996-08-02)
Different putative toxic amyloid beta (A beta) peptides, beta (1-42), beta (1-40) and beta (25-35), were infused (0.75, 1.5 or 3 nmol) in the rat medial septum. Memory deficits were then investigated using the social recognition test. A significant amnesia
Sherry Wolf et al.
European journal of cancer (Oxford, England : 1990), 44(11), 1507-1515 (2008-06-24)
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose limiting side effect of many commonly used chemotherapeutic agents, including platinum drugs, taxanes, epothilones and vinca alkaloids, and also newer agents such as bortezomib and lenolidamide. Symptom control studies have been conducted
Highlights From: the 2006 American Society of Clinical Oncology Gastrointestinal Cancers Symposium San Francisco, CA, January 2006.
Tara Beers Gibson et al.
Clinical colorectal cancer, 5(6), 398-402 (2006-04-26)
A Appert-Collin et al.
International journal of immunopathology and pharmacology, 17(2), 157-164 (2004-06-03)
Compounds possessing neurotrophic properties may represent a possible treatment for neurodegenerative disorders such as amyotrophic lateral sclerosis. Xaliproden (SR57746A), an orally-active non-peptide compound, which has been found to exhibit neurotrophic effects in vitro and in vivo, increased the lifespan and
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