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Key Documents

SML0513

Sigma-Aldrich

SKF83822 hydrobromide

Synonym(s):

6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propen-1-yl)-1H-3-Benzazepine-7,8-diol hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C20H22ClNO2 · HBr
CAS Number:
Molecular Weight:
424.76
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

storage temp.

2-8°C

Quality Level

SMILES string

Br.Cc1cccc(c1)C2CN(CCc3c(Cl)c(O)c(O)cc23)CC=C

InChI

1S/C20H22ClNO2.BrH/c1-3-8-22-9-7-15-16(11-18(23)20(24)19(15)21)17(12-22)14-6-4-5-13(2)10-14;/h3-6,10-11,17,23-24H,1,7-9,12H2,2H3;1H

InChI key

CFWPKYBBXBANLU-UHFFFAOYSA-N

Biochem/physiol Actions

SKF83822 is a dopamine receptor agonist that only activates the D1 monomers and stimulates adenylate cyclase, but not PI hydrolysis.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbonesEnvironment

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Yuji Odagaki et al.
Journal of receptor and signal transduction research, 39(1), 9-17 (2019-06-22)
Although multiple roles of dopamine through D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptors are initiated primarily through stimulation or inhibition of adenylyl cyclase via Gs/olf or Gi/o, respectively, there have been many reports indicating diverse signaling

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