Skip to Content
Merck
All Photos(2)

Documents

P1537

Sigma-Aldrich

Polyadenylic acid-Polyuridylic acid sodium salt

double-stranded homopolymer

Synonym(s):

Poly[A]•Poly[U]

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

CAS Number:
24936-38-7
MDL number:
MFCD00131949
UNSPSC Code:
41106305
NACRES:
NA.51

Quality Level

200

form

powder

storage temp.

−20°C

InChI

1S/C10H14N5O7P.C9H13N2O9P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1

InChI key

VGQHQOKIMNKUEF-ZLOOHWKQSA-N

Application

Polyadenylic acid-Polyuridylic acid (polyAU) is a double stranded homodimer studied for potential therapeutic activity, especially when coupled with radiotherapy. PolyA/U is used in comparative physiochemical studies with other duplex and single-stranded polymers such as poly-A and poly-U.

Other Notes

Double stranded homopolymer

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 2

1 of 2

Poly (A) Cytiva 27-4110-01, pack of 100 mg

GE27-4110-01

Poly (A)

Polyinosinic acid potassium salt Homopolymer

Sigma-Aldrich

P4154

Polyinosinic acid potassium salt

Polyadenylic acid-polyuridylic acid (poly A : U) and experimental murine brucellosis. II. Macrophages as target cells of poly A : U in experimental brucellosis.
E D Madraso et al.
Immunology, 35(1), 77-84 (1978-07-01)
A Laplanche et al.
Breast cancer research and treatment, 64(2), 189-191 (2001-02-24)
With a median follow-up of 14 years, the combination of polyadenylic-polyuridylic acid plus locoregional radiotherapy (257 patients) has significantly improved disease-free survival (p = 0.03) and significantly reduced the incidence of metastases (p = 0.04) when compared to CMF alone
Nino Lomadze et al.
Organic & biomolecular chemistry, 4(9), 1755-1759 (2006-04-25)
The affinities of polyamines consisting of ethylenediamine units equipped with either one or two terminal naphthyl-, anthryl-, or acridyl units towards PolyA.PolyU as an RNA model, and Poly(dA).Poly(dT) as a DNA model are screened by measuring the melting point changes
H-C Jeung et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 19(3), 520-526 (2007-11-22)
This phase III trial was to compare 5-fluorouracil (5-FU), adriamycin, and polyadenylic-polyuridylic acid (poly A:U) against 5-fluorouracil plus adriamycin (FA) for operable gastric cancer. From 1984 to 1989, patients who had D(2-3) curative resection were randomly assigned to receive chemotherapy
W Pohle et al.
Biopolymers, 67(6), 499-503 (2002-09-05)
We used FTIR spectroscopy to comparatively study the hydration of films prepared from nucleic acids (DNA and double-stranded RNA) and lipids (phosphatidylcholines and phosphatidylethanolamines chosen as the most abundant ones) at room temperature by varying the ambient relative humidity in
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service