M7397

L-(−)-Malic acid

suitable for cell culture, BioReagent, suitable for insect cell culture

• Synonym(s): (S)-(−)-2-Hydroxysuccinic acid, L-Hydroxybutanedioic acid
• Linear Formula: HO₂CCH₂CH(OH)CO₂H
• CAS Number: 97-67-6
• Molecular Weight: 134.09
• Beilstein: 1723541
• EC Number: 202-601-5
• MDL number: MFCD00064213
• UNSPSC Code: 12352205
• PubChem Substance ID: 24897161
• NACRES: NA.75

Properties

• biological source: microbial
• Quality Level: 200
• product line: BioReagent
• Assay: ≥95% (titration)
• form: powder
• technique(s): cell culture | insect: suitable; cell culture | mammalian: suitable
• mp: 101-103 °C (lit.)
• solubility: water: 100 mg/mL, clear to slightly hazy, colorless
• SMILES string: O[C@@H](CC(O)=O)C(O)=O
• InChI: 1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m0/s1
• InChI key: BJEPYKJPYRNKOW-REOHCLBHSA-N

Description

General description

Malic acid is used as a component of insect tissue culture. It is also useful as an acidulant in soft drinks, jams, fruit and vegetable juices.

Application

Malic acid has been used:

• to induce basal respiration in mitochondrial cell culture
• to measure the mitochondrial ETC (electron transport chain) activity
• as a component of mitochondrial substrate stock

Biochem/physiol Actions

Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion. Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders. A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves