M3895

Mucin from bovine submaxillary glands

Type I-S

• Synonym(s): MUC
• CAS Number: 84195-52-8
• EC Number: 282-357-4
• MDL number: MFCD00131629
• UNSPSC Code: 12352202
• NACRES: NA.61

Properties

• biological source: bovine submaxillary glands
• type: Type I-S
• form: powder
• composition: Bound sialic acids, 9-24%
• technique(s): electrophoresis: suitable
• UniProt accession no.: P98091
• storage temp.: −20°C
• Gene Information: cow ... BSM(286841)

Description

General description

Mucin from bovine submaxillary glands is encoded by two bovine submaxillary BSM genes. It is present in the saliva and interacts with air and food. Mucin comprises three major domains namely N- and C terminal and the glycosylated proline, threonine and serine (PTS domain) central domain. The sialic acid contributes to 30% of the molecular weight of mucin. The central domain has many tandem repeats.

Application

Mucin from bovine submaxillary glands has been used:

• in the quantification of mucin
• as a component of artificial tear solution
• as a substrate for recombinant sialidase Gardnerella vaginalis
• to investigate a galactose-specific lectin from the red marine alga Ptilota filicina
• to study the characterization of a unique mucin-like glycoprotein secreted by a human endometrial adenocarcinoma cell line (Ishikawa)

Biochem/physiol Actions

Bovine submaxillary mucin (BSM) is thermally stable up to 85°C. The terminal domain regions are key for the adsorption functionality of mucin.

Albuminoid substance in mucus which gives it its ropy consistency

Linkage

Similar to M 4503, but produced by Sigma.

Substrates

Neuraminidase substrate.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves