C6019 is supplied in powder form. It is soluble in Chloroform at 50.0 - 52.0 mg/ml. But the information on the absorption molecular coefficient of clotrimazole is currently unavailable. However, I conducted an extensive literature search and found some relevant information. Clotrimazole showed absorption maxima (λ max) at 263 nm, and linearity was obtained by concentration versus absorbance for clotrimazole with a correlation coefficient of r = 0.999.
C6019
Clotrimazole
98.5-100.5% (dry basis), powder, Ca²⁺-activated K⁺ channels inhibitor
Synonym(s):
1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
About This Item
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Product Name
Clotrimazole,
form
powder
Quality Level
antibiotic activity spectrum
fungi
Mode of action
cell membrane | interferes
protein synthesis | interferes
originator
Schering Plough
SMILES string
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
InChI
1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChI key
VNFPBHJOKIVQEB-UHFFFAOYSA-N
Gene Information
human ... ABCB1(5243) , CYP17A1(1586) , CYP3A4(1576)
mouse ... Abcb1a(18671) , Abcb1b(18669)
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General description
Application
- to study the upregulation of the gene ERG11 that codes for an azole target enzyme lanosterol demethylase, in Candida species, upon treatment with azole antibiotics[1]
- to study the development of resistance in Candida species isolated from patients undergoing prolonged antifungal treatment[2]
- to induce stress granules via mitochondrial stress[3][4]
- for the inhibition of in vitro formation of high density sickle cells induced by treatment with 1-chloro-2,4-dinitrobenzene (CDNB)[5]
- to inhibit cytochrome P450 enzyme in cell cultures[6]
Biochem/physiol Actions
Features and Benefits
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
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Please provide the absorption molecular coefficient of clotrimazole and the solvent used to quantify my clotrimazole solutions.
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