23182
(+)-1-(9-Fluorenyl)ethyl chloroformate solution
≥18 mM in acetone, for chiral derivatization, LiChropur™
Synonym(s):
(+)-FLEC solution
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About This Item
Empirical Formula (Hill Notation):
C16H13ClO2
CAS Number:
Molecular Weight:
272.73
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
grade
for chiral derivatization
Quality Level
product line
ChiraSelect™
optical purity
enantiomeric ratio: ≥99.0:1.0 (HPLC)
quality
LiChropur™
concentration
≥18 mM in acetone
technique(s)
HPLC: suitable
refractive index
n20/D 1.359
storage temp.
2-8°C
InChI
1S/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3
InChI key
SFRVOKMRHPQYGE-UHFFFAOYSA-N
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General description
(+)-1-(9-Fluorenyl)ethyl chloroformate [(+)-FLEC] is a chiral derivatizing reagent. It helps in separating enantiomers of α-amino acids, as well as helps in determining its optical purity using HPLC method.
Application
(+)-FLEC may be used in enantioselective analysis of glufosinate using reversed-phase high-performance liquid chromatography system coupled with a fluorescence detection system.
Physical form
solution, 5 mg in 1 mL acetone
Other Notes
Chiral derivatizing agent for primary and secondary amino acids and amines. The derivatives are separated by reversed-phase LC with fluorescence detection for determining the enantiomeric purity
Legal Information
ChiraSelect is a trademark of Sigma-Aldrich Co. LLC
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
Target Organs
Central nervous system
Supplementary Hazards
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
1.4 °F
Flash Point(C)
-17 °C
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Separation of amino acid enantiomers and chiral amines using precolumn derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate and reversed-phase liquid chromatography.
S Einarsson et al.
Analytical chemistry, 59(8), 1191-1195 (1987-04-15)
Yasushi Hori et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 776(2), 191-198 (2002-07-26)
We have developed a new analytical method to quantify the DL-homoalanine-4-yl(methyl)phosphinate (DL-GLUF) enantiomers in biological specimens using a reversed-phase high-performance liquid chromatography system with a fluorescence detection system. The derivatization of DL-GLUF enantiomers with (+)-1-(9-fluorenyl)ethyl chloroformate was carried out under
Identifying the carboxy terminal amino acid of a protein.
T H Akiyama et al.
Methods in molecular biology (Clifton, N.J.), 64, 235-242 (1997-01-01)
E Frigerio et al.
Journal of chromatography. A, 660(1-2), 351-358 (1994-02-04)
A sensitive and selective high-performance liquid chromatographic method for the determination of reboxetine enantiomers in human plasma was developed. Although two chiral centres are present in reboxetine, its stereospecific synthesis leads to two rather than four possible enantiomers. After extraction
Zeineb Aturki et al.
Electrophoresis, 25(4-5), 607-614 (2004-02-26)
The indirect resolution of five beta-adrenoreceptor blocking agents (propranolol, oxprenolol, pindolol, metoprolol, and atenolol) using precolumn derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate (FLEC), and capillary electrochromatography (CEC) is reported. Three octadecylsilanized (ODS) silica gel-based stationary phases, differing in particle diameter and carbon
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