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Key Documents

8.00894

Sigma-Aldrich

N-Ethyldiisopropylamine

for synthesis

Synonym(s):

N-Ethyldiisopropylamine, N,N-Diisopropylethylamine

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About This Item

Linear Formula:
[(CH3)2CH]2NCH2CH3
CAS Number:
Molecular Weight:
129.24
MDL number:
UNSPSC Code:
12352116
EC Index Number:
230-392-0
NACRES:
NA.22

vapor pressure

14 hPa ( 20 °C)

Quality Level

Assay

≥98% (GC)

form

liquid

autoignition temp.

240 °C

potency

200-500 mg/kg LD50, oral (Rat)

expl. lim.

0.7-6.3 % (v/v)

pH

12.3 (20 °C in H2O, as an emulsion)

kinematic viscosity

0.88 cSt(20 °C)

bp

127 °C/1013 hPa

transition temp

flash point 9.5 °C

density

0.76 g/cm3 at 20 °C

storage temp.

2-30°C

InChI

1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3

InChI key

JGFZNNIVVJXRND-UHFFFAOYSA-N

General description

N,N-Diisopropylethylamine (DIPEA), also known as Hunig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed in substitution reactions, alkylations, amide couplings, etc. DIPEA is also used as a base in the Pd-catalyzed cross-coupling reactions, which include Heck coupling and Sonagashira coupling reactions.

Application

  • Dual Stimuli-Responsive Hybrid Polymeric Nanoparticles Self-Assembled from POSS-Based: Describes the synthesis of hybrid polymeric nanoparticles using N-Ethyldiisopropylamine in the assembly process (Yang et al., 2022).
  • Magnetical Control of the Charge-Separated State Lifetime Realized by Covalent Attachment of a Platinum Complex: Details the use of N-Ethyldiisopropylamine in the preparation of magnetically controllable platinum complexes (Kozaki et al., 2021).
  • Hybrid block copolymers of polyesters/polycarbonates and polypeptides synthesized via one-pot sequential ring-opening polymerization: Explains the initiation of polymerization with N-Ethyldiisopropylamine for creating hybrid block copolymers (Gradišar et al., 2018).

Analysis Note

Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 0.755 - 0.758
Water (K. F.): ≤ 0.20 %
Identity (IR): passes test

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.1 °F

Flash Point(C)

9.5 °C


Certificates of Analysis (COA)

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Protocols

Fmoc resin cleavage and deprotection are crucial steps for peptide synthesis, yielding the desired peptide after resin detachment.

Fmoc resin cleavage and deprotection are crucial steps for peptide synthesis, yielding the desired peptide after resin detachment.

Fmoc resin cleavage and deprotection are crucial steps for peptide synthesis, yielding the desired peptide after resin detachment.

Fmoc resin cleavage and deprotection are crucial steps for peptide synthesis, yielding the desired peptide after resin detachment.

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