Skip to Content
Merck
All Photos(1)

Documents

C66056

Sigma-Aldrich

4-(4-Chlorophenyl)-4-hydroxypiperidine

99%

Synonym(s):

Haloperidol metabolite I, 4-(4-Chlorophenyl)-4-hydroxypiperidine, 4-(4-Chlorophenyl)-4-piperidinol

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C11H14ClNO
CAS Number:
39512-49-7
Molecular Weight:
211.69
EC Number:
254-479-8
MDL number:
MFCD00006001
UNSPSC Code:
12352100
PubChem Substance ID:
24892880
NACRES:
NA.22

Quality Level

100

Assay

99%

form

powder

mp

137-140 °C (lit.)

SMILES string

OC1(CCNCC1)c2ccc(Cl)cc2

InChI

1S/C11H14ClNO/c12-10-3-1-9(2-4-10)11(14)5-7-13-8-6-11/h1-4,13-14H,5-8H2

InChI key

LZAYOZUFUAMFLD-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H315,H317,H318,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Yasuhiko Higashi et al.
Biomedical chromatography : BMC, 20(9), 964-970 (2006-03-01)
4-(4-Chlorophenyl)-4-hydroxypiperidine (CPHP), one of the metabolites of haloperidol, is considered to exhibit brain toxicity. CPHP concentrations in plasma and tissue homogenates (each 200 microL) from rats were analyzed by HPLC fluorescence detection after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F). After basic
J Fang et al.
Journal of chromatography. B, Biomedical applications, 682(2), 283-288 (1996-07-12)
An electron-capture gas chromatographic procedure was developed for the analysis of 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a metabolite of haloperidol. The assay involved basic extraction of this metabolite from the biological samples, followed by back-extraction with HCl. After basification of the acid phase
Ilse Weuts et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 25(4-5), 387-393 (2005-05-17)
The purpose of the study was to investigate the suitability of polyacrylic acid (PAA) as a carrier in solid dispersions, with the aim to delay crystallization of basic drugs and improve their dissolution behaviour. The physicochemical properties were investigated in
A B Skorniakova et al.
Sudebno-meditsinskaia ekspertiza, 52(1), 45-48 (2009-04-18)
Haloperidol is extensively used in current psychiatric practice for the treatment of various psychotic disorders. However, this substance is known to be toxic and sometimes cause poisoning despite its generally positive therapeutic effect. Moreover, some of its metabolites also possess
L P Pan et al.
Pharmacogenetics, 8(5), 383-389 (1998-11-24)
In-vitro studies were performed using human liver microsomes and c-DNA-expressed human P450 isoforms to identify the cytochrome P450 isoenzyme(s) involved in the back oxidation and N-dealkylation of reduced haloperidol. Back oxidation and N-dealkylation of reduced haloperidol were assessed by measuring
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service