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Key Documents

900401

Sigma-Aldrich

SLAP 2,3-Bicyclo-(3,4-THF) N-BnPip Reagent

≥95%

Synonym(s):

trans-N3-Benzyl-N3-((trimethylsilyl)methyl)tetrahydrofuran-3,4-diamine

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About This Item

Empirical Formula (Hill Notation):
C15H26N2OSi
Molecular Weight:
278.47
UNSPSC Code:
12352103
NACRES:
NA.22

Quality Level

Assay

≥95%

form

liquid

refractive index

n/D 1.520

density

1.000 g/mL

storage temp.

−20°C

Application

Silicon amine protocol (SLAP) reagents, in conjunction with aldehydes and ketones, form N-unprotected piperazines via photocatalytic cross-coupling with Ir[(ppy)2dtbbpy]PF6 (747769). Heteroaromatic, aromatic, and aliphatic aldehydes are well tolerated, as are structurally and stereochemically complex SLAP reagents. This product was introduced in collaboration with the Bode Research Group and provides a tin-free alternative to SnAP (tin amine protocol) reagents for piperazine synthesis.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3


Certificates of Analysis (COA)

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