No; Sigma-Aldrich has no source for pure 2,3,7,8-Tetrachlorodibenzo-p-dioxin. It is only available as Supelco 48599: 2,3,7,8-TCDD, 10 μg/mL in toluene, ampule of 1mL.
48599
2,3,7,8-Tetrachlorodibenzo-p-dioxin solution
analytical standard
Synonym(s):
2,3,7,8-TCDD
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About This Item
Pricing and availability is not currently available.
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grade
analytical standard
CofA
current certificate can be downloaded
packaging
ampule of 1 mL
storage temp.
2-8°C
InChI
1S/C12H4Cl4O2/c13-5-1-9-10(2-6(5)14)18-12-4-8(16)7(15)3-11(12)17-9/h1-4H
InChI key
HGUFODBRKLSHSI-UHFFFAOYSA-N
General description
2,3,7,8-Tetrachlorodibenzo-p-dioxin is a highly distributed environmental contaminant[1], released by industrial activities, which can act like as a reproductive toxicant and endocrine disruptor in all vertebrates.[2]
2,3,7,8-Tetrachlorodibenzo-p-dioxin is the most potent congener of dioxins and dioxin-like chemicals, which can exert adverse effects in laboratory animals used in testing.[3]
Application
2,3,7,8-Tetrachlorodibenzo-p-dioxin solution has been used as standard in investigating the effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin to offsprings of fish, using high performance gas chromatography coupled with high performance mass spectrometry (HPGC-HPMS).[2]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 1 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3
Target Organs
Central nervous system
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
39.2 °F - closed cup
Flash Point(C)
4 °C - closed cup
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E C Rada et al.
Chemosphere, 110, 53-61 (2014-06-02)
Atmospheric depositions of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) were monitored at three sites in the vicinity of a steel making plant, located in an Italian alpine valley. A high variability in the deposition of PCDD/Fs was
K A Solak et al.
Toxicology, 311(3), 124-134 (2013-07-23)
The aryl hydrocarbon receptor (AhR) is involved in a wide variety of biological and toxicological responses, including neuroendocrine signaling. Due to the complexity of neuroendocrine pathways in e.g. the hypothalamus and pituitary, there are limited in vitro models available despite
Filomena Fiorito et al.
Toxicology, 290(2-3), 258-270 (2011-10-22)
The administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to a variety of cultured cells may alter their ability to proliferate and die. In a previous study we demonstrated that TCDD induced proliferation in Madin-Darby Bovine Kidney (MDBK) cells where no signs of apoptosis
Maria Herlin et al.
Toxicology and applied pharmacology, 273(1), 219-226 (2013-09-17)
Bone is a target for high affinity aryl hydrocarbon receptor (AHR) ligands, such as dioxins. Although bone morphology, mineral density and strength are sensitive endpoints of dioxin toxicity, less is known about effects on bone microarchitecture and material properties. This
Hongtao Shang et al.
Environment international, 54, 50-58 (2013-02-19)
A total of 60 paired samples of earthworm, corresponding soil and wormcast were collected to investigate the bioaccumulation tendency of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in earthworms from a typical E-waste dismantling area in
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Can I get pure 2,3,7,8-Tetrachlorodibenzo-p-dioxin from Sigma-Aldrich?
1 answer-
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Is Product No. 48599, 2,3,7,8-Tetrachlorodibenzo-p-dioxin solution, appropriate for use in tissue culture studies?
1 answer-
The 2,3,7,8-Tetrachlorodibenzo-p-dioxin solution (10 μg/mL in toluene), is sold as 1mL in a flame sealed ampule. It is made to be used as a chemical standard with US EPA drinking and wastewater analytical methods. We have no knowledge of its use in tissue culture.
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What is the molecular weight of 2,3,7,8-Tetrachlorodibenzo-p-dioxin, Product 48599?
1 answer-
The molecular weight of 2,3,7,8-TCDD is 321.97 Da.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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